Potential therapeutic uses
- Anticancer: Wogonin has been shown in preclinical studies to inhibit the growth of various cancer cells, including those from leukemia, breast, and gastric cancers. It appears to do this by affecting cell signaling pathways involved in cancer development.
- Anti-inflammatory: It has demonstrated anti-inflammatory effects, which have been explored for conditions like atherosclerosis and atopic dermatitis.
- Antiviral: Wogonin has shown promise in preventing early viral infections, such as hepatitis B virus (HBV).
- Neuroprotection: Research suggests it may have a protective effect on the central nervous system (CNS), potentially aiding in the treatment of conditions like Alzheimer’s disease, cerebral ischemia, and other neurodegenerative diseases.
- Respiratory health: Wogonin may act as a mucoregulator, which could be helpful in managing chronic airway diseases by regulating mucus secretion.
Traditional and pharmacological context
- Wogonin is a major active compound found in the root of Scutellaria baicalensis (Baikal skullcap), which has been used for centuries in traditional Chinese medicine.
- Its use in both traditional medicine and modern research points to a wide range of potential benefits.
- While the research is promising, much of the evidence comes from preclinical studies, and more clinical trials are needed to confirm its effectiveness and safety in humans
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