Cissus quadrangularis is a vine used in traditional medicine for its anti-inflammatory, pain-relieving, and antioxidant effects. The extract has been studied for its potential benefits in bone and joint health, weight management, and other conditions. The plant is known as “Hadjod” or “bone-setter” in some regions due to its traditional use in healing bone fractures.
Potential health benefits
- Bone health and healing: Cissus quadrangularis is known for its ability to promote bone health and accelerate the healing of bone fractures. It stimulates the proliferation of bone-forming cells and increases bone mineral density. A 2025 review in the journal BMC Complementary Medicine and Therapies focused on its potential to improve bone-related biomarkers in humans.
- Joint pain: Due to its anti-inflammatory properties, cissus quadrangularis may help reduce joint pain, inflammation, and stiffness associated with conditions like arthritis. Athletes and bodybuilders also use it to aid in recovery from exercise-induced joint injuries.
- Weight management: Some studies suggest that cissus quadrangularis extract, especially when combined with other supplements, may help with weight loss by suppressing appetite and regulating metabolism.
- Metabolic health: Research indicates that the extract may help manage components of metabolic syndrome, such as high blood sugar and cholesterol levels.
- Muscle recovery: The supplement may aid in muscle repair and reduce post-workout soreness, making it popular among athletes.
Products and availabilityCissus quadrangularis extract is widely available as a dietary supplement in various forms, often containing a standardized amount of active compounds, such as ketosteroids.

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