Zyrex Ayurveda Camptotheca Acuminata Extract Powder -1 KG Pack

Specific medicinal uses:

Cancer treatment:
Camptothecin and its derivatives, like topotecan and irinotecan, are used to treat various types of cancer, including ovarian, cervical, and colorectal cancer.

Other traditional uses:
Camptotheca acuminata has also been used in traditional Chinese medicine to treat psoriasis, liver ailments, stomach problems, and common colds.
Antifungal properties:
Some research suggests that camptothecin, isolated from the plant, may have antifungal properties.

How it works:

Topoisomerase I inhibition:
Camptothecin inhibits an enzyme called topoisomerase I, which is crucial for DNA replication and repair.
DNA damage and cell death:
By inhibiting topoisomerase I, camptothecin prevents the cell from properly repairing DNA, leading to DNA damage and ultimately, cell death.

Important notes:

Side effects:
Like other anticancer drugs, camptothecin and its derivatives can cause side effects, such as myelosuppression (bone marrow suppression), diarrhea, and cholinergic excess (salivation, lacrimation, diaphoresis, and abdominal cramping).

Synthetic alternatives:
Due to low yields from the plant, synthetic routes and semi-synthetic analogues like topotecan and irinotecan have been developed to meet the demand for these anticancer drugs.
Toxicity:
It’s important to note that the leaves and fruit of Camptotheca acuminata can be toxic if ingested, and supportive treatment, including activated charcoal therapy, may be needed in case of poisoning